September 30 - St. Francis Borgia, Jesuit priest (b. 1510)
November 24 - John Knox, Scottish reformer (b. 1510)
Events
January 16 - Thomas Howard, 4th Duke of Norfolk is tried for treason for his part in the Ridolfi plot to restore Catholicism in England.
April 1 - In the Eighty Years' War, the Watergeuzen capture Brielle from the Spaniards, gaining the first foothold on land for what would become the Dutch Republic.
August 18 - Marriage in Paris of the future Huguenot King Henry IV of Navarre to Marguerite de Valois, in a supposed attempt to reconcile Protestants and Catholics.
