June 19 - Matthäus Merian, Swiss engraver (b. 1593)
August 25 - Richard Crashaw, English poet (b. ca. 1613)
November 24 - Manuel Cardoso, Portuguese composer (b. 1566)
Events
April 27 - The Battle of Carbisdale: A Royalist army invades mainland Scotland from Orkney Island but is defeated by a Covenanter army.
June 9 - The Harvard Corporation, the more powerful of the two administrative boards of Harvard, is established. It is the first legal corporation in the Americas.
September 3 - Third English Civil War: Battle of Dunbar (1650)
September 29 - Henry Robinson opens his Office of Addresses and Encounters
