May 18 - Battle of Las Piedras: The first great military triumph of the revolution of the Río de la Plata in Uruguay lead by Jose Artigas.
July 5 - Venezuela declares independence from Spain.
July 11 - Italian scientist Amedeo Avogadro publishes his memoir about molecular content of gases.
September 4 - Chileans independentist execute a coup d'état against the Spanish controlled Junta of the country.
October 1 - The first steamboat to sail the Mississippi River arrives in New Orléans, Louisiana.
October 11 - Inventor John Stevens' boat, the Juliana, begins operation as the first steam-powered ferry (service between New York, New York, and Hoboken, New Jersey).
November 7 - Tecumseh's War: The Battle of Tippecanoe is fought near present-day Battle Ground, Indiana, United States.
November 17 - José Miguel Carrera, Chilean founding father, is sworn in as President of the executive Junta of the government of Chile.
December 16 - The first two in a series of severe earthquakes occurs, in the vicinity of New Madrid, Missouri. These three so-called Mega-quakes are believed to be an ongoing cataclysmic danger that could reprise the 1811-12 series of 2,000 quakes that affected the lands of what would be eight of today's heartland states of the United States.
December 26 - A theater fire in Richmond, Virginia kills the Governor of Virginia George William Smith and the president of the First National Bank of Virginia Abraham B. Venable.